2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

Related Products

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-138502
    Melarsomine
    		Inhibitor
    Melarsomine is a trivalent arsenical compound used as an adulticide. Melarsomine can be used for the reserach of canine heartworm disease and other helminth infections.
    Melarsomine
  • HY-B1751S
    Quinidine-d3
    		Inhibitor
    Quinidine-d3 is the deuterium labeled Quinidine. Quinidine is an antiarrhythmic agent for the treatment of abnormal heart rhythms and also malaria.
    Quinidine-d<sub>3</sub>
  • HY-174343
    ELQ-121
    		Inhibitor
    ELQ-121 is a potent inhibitor of the ubiquinol-oxidation (QO)-site of parasites. ELQ-121 has IC50 of 0.05 nM against chloroquine sensitive and multidrug resistant P. falciparum in vitro. ELQ-121 inhibits T. gondii and N. caninum with IC50 below 1 nM in vitro. ELQ-121 suppresses B. besnoiti tachyzoite proliferation with an IC50 of 0.49 nM and induces mitochondrial disruption. ELQ-121 can form polyethylene glycol carbonate ester prodrug which demonstrates in vivo efficacy against P. yoelii in mice. ELQ-121 is suitable for antimalarial research.
    ELQ-121
  • HY-B0803S
    Lumefantrine-d18
    		Inhibitor
    Lumefantrine-d18 is the deuterium labeled Lumefantrine, which is an antimalarial agent.
    Lumefantrine-d<sub>18</sub>
  • HY-156132
    DNDI-0690
    		Inhibitor
    DNDI-0690 is a potent orally active analogue of DNDI-VL-2098, exhibiting potent activity against cutaneous leishmaniasis (CL). DNDI-0690 shows potent in vitro activity against CL-causing Leishmania species (EC50 = 0.17 μM against visceral leishmaniasis (VL), and < 5 μM against CL-causing species). DNDI-0690 exerts effects in a mouse model of L. major CL. DNDI-0690 can be used for CL research.
    DNDI-0690
  • HY-B1004R
    Dinitolmide (Standard)
    		Inhibitor
    Dinitolmide (Zoalene) (Standard) is the analytical standard of Dinitolmide (HY-B1004). This product is intended for research and analytical applications. Dinitolmide is an orally active anticoccidial agent used as a fodder additive. Dinitolmide has a wide anticoccidial spectrum with no effect on host immunity. Dinitolmide mainly acts on the first generation merozoite stage of coccidia and also has an inhibitory effect on the sporulation process of oocysts. Dinitolmide has anti-Toxoplasma gondii effect in vitro with an EC50 of 3.625 μg/mL. Dinitolmide can be used to inhibits infections caused by Eimeria tenella.
    Dinitolmide (Standard)
  • HY-P5696
    Xenopsin precursor fragment
    		Inhibitor
    Xenopsin precursor fragment is an antimicrobial peptide, and has antibacterial/antifungal (10-500 μg/mL) and anti-protozoal (MIC: 2-20 μg/mL) activity.
    Xenopsin precursor fragment
  • HY-N3247
    Monomethyl kolavate
    		Inhibitor
    Monomethyl kolavate is a Trypanosoma brucei GAPDH enzyme (TbGAPDH) inhibitor with theIC50 value of 2 µM.
    Monomethyl kolavate
  • HY-144098
    HDAC8-IN-2
    		Inhibitor
    HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor, with IC50 values of 0.27 and 0.32 μM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. HDAC8-IN-2 shows significant killing of the schistosome larvae. HDAC8-IN-2 markedly impairs egg laying of adult worm pairs.
    HDAC8-IN-2
  • HY-139672
    BRD5018
    		Inhibitor
    BRD5018 is an antimalarial agent. BRD5018 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    BRD5018
  • HY-N3378
    Lipiferolide
    		Inhibitor
    Lipiferolide is an antiplasmodial agent (IC50: 1.8 μg/mL) that can be isolated from Liriodendron tulipifera. Lipiferolide also inhibits FPTase, and has antitumor activity.
    Lipiferolide
  • HY-114614
    Clenpirin
    		Inhibitor
    Clenpirin is a insecticide against cattle ticks Boophilus microplus. Clenpirin exhibits slightly toxicity to rats with LD50 of 3050 mg/kg.
    Clenpirin
  • HY-W1004917
    8,9-Z-Abamectin B1a
    		Inhibitor
    8,9-Z-Abamectin B1a is the 8,9-Z-isomer of Abamectin B1a (HY-15308). Avermectin B1a is an antiparasitic agent that paralyzes nematodes.
    8,9-Z-Abamectin B1a
  • HY-161666
    mCMY416
    		Inhibitor
    mCMY416 is an orally active and blood brain barrier (BBB) permeability apicomplexan phenylalanine tRNA synthetase inhibitor, and shows antiparasitic activity .
    mCMY416
  • HY-159097
    T.cruzi-IN-4
    		Inhibitor
    T.cruzi-IN-4 (Compound 21) is an anti-parasitic agent. T.cruzi-IN-4 inhibits the trypomastigote and amastigote form of Trypanosoma cruzi with IC50 of 0.033 μM (120 h), T.cruzi-IN-4 inhibits the promastigote and amastigote form of Leishmania infantum with IC50 of 28.74 and 61.82 μM. T.cruzi-IN-4 inhibits Leishmania amazonensis promastigote form with IC50 of 18.38 μM.
    T.cruzi-IN-4
  • HY-N16426
    Mycoleptone A
    		Inhibitor
    Mycoleptone A is an azafluorenone compound. Mycoleptone A exhibits certain anti-leishmanial activity, with an LD50 of 28.5 μM against L. major. Mycoleptone A shows cytotoxicity against human prostate cancer cell line PC3, with an IC50 of 10.0 μM. Mycoleptone A can be used in research on anti-parasitic and anti-tumor aspects.
    Mycoleptone A
  • HY-121477R
    Resorantel (Standard)
    		Inhibitor
    Resorantel (Standard) is the analytical standard of Resorantel. This product is intended for research and analytical applications. Resorantel is an anthelmintic. Resorantel is used in the research of paramphistomiasis in cattle and sheep and has also been used for the research of G. aegypticus.
    Resorantel (Standard)
  • HY-N3283
    6-Methylhydroxyangolensate
    		Inhibitor
    6-Methylhydroxyyangolensate is a limonoid can be extracted from Khaya grandifoliola. 6-Methylhydroxyyangolensate has low antimalarial activity in vitro, with an IC50 of 21.59 μg/ml against P. falciparum (W2/Indochina clone).
    6-Methylhydroxyangolensate
  • HY-153238
    AN15368
    		Inhibitor
    AN15368 is an orally active trypanocidal agent and a prodrug of AN14667. AN15368 selectively targets CPSF3-mediated mRNA maturation in intracellular amastigotes of Trypanosoma cruzi, reducing the mRNA levels of the parasite. As a prodrug, AN15368 can be cleaved into its active carboxylate form by CBP of Trypanosoma cruzi. AN15368 completely clears long-term naturally acquired Trypanosoma cruzi infections in non-human primates. AN15368 can be used in the research of Chagas disease.
    AN15368
  • HY-145812
    CRK12-IN-1
    		Inhibitor
    CRK12-IN-1 is a potent CRK12 inhibitor. CRK12-IN-1 is extremely potent against T.b. brucei and rapidly cytocidal, as well as equally potent against T. congolense and T. vivax (EC50 of 1.3 and 18 nM, respectively).
    CRK12-IN-1
Parasite Isoform Comparison

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